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司张勇简介

 

      司张勇   

 

     司张勇

                 中国科学院宁波材料技术与工程研究所研究员

     教育经历：

                 2014.8-2019.12，博士（Ph.D.），新加坡南洋理工大学，化学与生物医药工程专业

                 2010.9-2014.7，学士（B.S.），苏州大学，材料化学专业

     工作经历：

                 2024.7-今，中科院宁波材料所，新型药物制剂材料与技术团队，研究员

                 2020.2–2024.4，新加坡南洋理工大学化学与生物医药工程学院，顾问、研究员、客聘教职

     研究方向：

                研究方向专注于抗菌高分子材料及其制剂技术的开发与应用，致力于为应对日益严重的抗菌耐药性问题提供创新解决方案。主要包括以下三个方面：（1）新型抗菌高分子材料的设计与合成，特别是阳离子聚合物和抗菌肽类。（2）制剂技术的开发，致力于研发先进的药物制剂技术，如可控释放系统和靶向递送平台。（3）新靶点及作用机制的探索， 寻找新的抗菌干预靶点。

     科研项目：

                国家自然科学基金（青年科学基金项目），项目经费30万， 2025年

                中国科学院宁波材料工程与技术研究“团队人才”项目 ，项目经费400万，2024年

     个人学术成绩：

  1. Si, Z.;  Sun, Y.;  Tan, C.;  Ooi, Y. J.;  Li, M.;  Raju, C.;  Shubi, J.;  Gan, Y.-H.;  Zhu, Y.; Li, P., A cationic main-chain poly (carbonate-imidazolium) potent against Mycobacterium abscessus and other resistant bacteria in mice. Biomaterials 2025, 316, 123003.
  2. Zhou, Q.; Li, K.; Wang, K.;  Hong, W.;  Chen, J.;  Chai, J.;  Yu, L.;  Si, Z.; Li, P., Fluoroamphiphilic polymers exterminate multidrug-resistant Gram-negative ESKAPE pathogens while attenuating drug resistance. Science Advances 2024, 10 (35), eadp6604.
  3. Shabani, S.; Hadjigol, S.; Li, W.; Si, Z.; Prananty, D; Chan-Park, M. B.; O’Brien-Simpson, N.M.; Qiao, G.G. “Synthetic peptide branched polymers for antibacterial and biomedical applications” Nature Review Bioengineering 2024, 2 (4), 343-361.
  4. Wei, G.;  Yue Feng, M. T.;  Si, Z.; Chan-Park, M. B., Single-cell oral delivery platform for enhanced acid resistance and intestinal adhesion. ACS Applied Materials & Interfaces 2024, 16 (17), 21498-21508.
  5. Si, Z.; Li. J.; Ruan, L.; Reghu, S.; Ooi, Y.; Li, P.; Zhu, Y.; Hammond, P. T.; Verma, C. S.; Bazan, G. C.; Pethe, K.; Chan-Park, M. B. “Designer co-beta-peptide copolymer selectively targets resistant and biofilm Gram-negative bacteria” Biomaterials 2023, 294, 122004.
  6. Si, Z.; Pethe, K.; Chan-Park, M. B. “Chemical Basis of Combination Therapy to Combat Antibiotic Resistance” JACS Au 2023, 3 (2), 276-292.
  7. Qiu, H.; Deng, J.; Wei, R.; Wu, X.; Chen, S.; Yang, Y.; Gong, C.; Cui, L.; Si, Z.; Zhu, Y.; Wang, R.; Xiong, D. “A lubricant and adhesive hydrogel cross-linked from hyaluronic acid and chitosan for articular cartilage regeneration” International Journal of Biological Macromolecules 2023, 243, 125249.
  8. Chen, H.; Yong, M.; Li, M.; Si, Z.; Koh, C. H.; Lau, P.; Chang, Y.; Teo, J.; Chan-Park, M. B.; Gan, Y.-H. “A hydrophilic polyimidazolium antibiotic targeting the membranes of Gram-negative bacteria” Journal of Antimicrobial Chemotherapy 2023, Doi: 10.1093/jac/dkad274.
  9. Zhou, Q.#; Si, Z. # (co-first); Wang, K.; Li, K.; Hong, W.; Zhang, Y.; Li, P. “Enzyme-triggered Smart Antimicrobial Drug Release Systems against Bacterial Infections” Journal of Controlled Release 2022, 352, 507-526. 
  10. Si, Z.; Zheng, W.; Prananty, D; Li, J; Chong, H.K.; Kang, E-T; Pethe, K.; Chan-Park, M. B. “Polymers as advanced antibacterial and antibiofilm agents for direct and combination therapies” Chemical Science 2022, 13 (2), 345-364.
  11. Mon, K.; Si, Z.; Chan-Park, M. B.; Kenney, L. “Polyimidazolium protects against an invasive clinical isolate of Salmonella Typhimurium” Antimicrobial Agents and Chemotherapy, 2022, DOI: 10.1128/aac.00597-22.
  12. Pranantyo, D.; Zhang. K.; Si, Z.; Hou, Z.; Chan-Park, M. B. "Smart multifunctional polymer systems as alternatives or supplements of antibiotics to overcome bacterial resistance” Biomacromolecules 2022, DOI: 10.1021/acs.biomac.1c01614.
  13. Si, Z. ; Hou, Z. ; Vikhe, Y.; Thappeta, K.; Marimuthu, K.; De, P. P.; Ng, O. T.; Li, P.; Zhu, Y.; Pethe, K.; Chan-Park, M. B. “Antimicrobial Effect of a Novel Chitosan Derivative and Its Synergistic Effect with Antibiotics” ACS Appl. Mater. Interfaces 2021, 13 (2), 3237-3245. 
  14. Wu Y. ; Raju, C.; Hou, Z.; Si, Z.; Xu C.; Pranantyo, D.; Marimuthu, K.; De, P. P.; Ng, O. T.; Pethe, K.; Kang E-T.; Chan-Park, M. B. “Mixed-charge pseudo-zwitterionic copolymer brush as broad spectrum antibiofilm coating” Biomaterials 2021, DOI: 10.1016/j.biomaterials.2021.120794.
  15. Kim ,C-J; Si, Z.; Reghu S.; Guo Z.; Zhang K.; Li J.; Chan-Park, M. B. “DNA-derived Nanostructures Selectively Capture Gram-Positive Bacteria” Drug Deliv. Transl. Res. 2021, DOI: 10.1007/s13346-021-00975-w
  16. Qiu, H. #; Si, Z. # (co-first); Luo, Y.; Feng, P.; Wu, X.; Hou, W.; Zhu, Y.; Chan-Park, M. B.; Xu, L.; Huang, D. “The Mechanisms and the Applications of Antibacterial Polymers in Surface Modification on Medical Devices” Front. Bioeng. Biotechnol. 2020 8, 1.
  17. Si, Z.; Lim, H. W.; Tay, M. Y. F.; Du, Y.; Ruan, L.; Qiu, H.; Zamudio-Vazquez, R.; Reghu, S.; Chen, Y.; Tiong, W. S.; Marimuthu, K.; De, P. P.; Ng, O. T.; Zhu, Y.; Gan, Y.-H.; Chi, Y. R.; Duan, H.; Bazan, G. C.; Greenberg, E. P.; Chan-Park, M. B.; Pethe, K. “A glycosylated cationic block poly(β‐peptide) reverses intrinsic antibiotic resistance in all ESKAPE Gram‐negative bacteria” Angewandte Chemie International Edition 2020, 59 (17), 6819-6826.  (Science 专篇评论文章：https://www.science.org/content/blog-post/new-bacteria-killing-combination）
  18. Pranantyo, D.; Raju, C.; Si, Z.; Xu, X.; Pethe, K.; Chan-Park, M. B. “Nontoxic Antimicrobial Cationic Peptide Nanoconstructs with Bacteria-Displaceable Polymeric Counteranions” Nano Lett. 2020 doi.org/10.1021/acs.nanolett.0c03261.
  19. Zhang, K.#; Du, Y.#; Si, Z.# (co-first); Liu, Y#.; Turvey, M. E.; Raju, C.; Keogh, D.; Ruan, L.; Jothy, S. L.; Reghu, S.; Marimuthu, K.; De, P. P.; Ng, O. T.; Mediavilla, J. R.; Kreiswirth, B. N.; Chi, Y. R.; Ren, J.; Tam, K. C.; Liu, X.-W.; Duan, H.; Zhu, Y.; Mu, Y.; Hammond, P. T.; Bazan, G. C.; Pethe, K.; Chan-Park, M. B. “Enantiomeric glycosylated cationic block co-beta-peptides eradicate Staphylococcus aureus biofilms and antibiotic-tolerant persisters” Nature Communications 2019, 10, 1-14.
  20. Wong, E. H.; Khin, M. M.; Ravikumar, V.; Si, Z.; Rice, S. A.; Chan-Park, M. B. “Modulating antimicrobial activity and mammalian cell biocompatibility with glucosamine-functionalized star polymers.” Biomacromolecules 2016, 17, 1170.
  21. Pan, J.; Miao, J.; Zhang, L.; Si, Z.; Zhang, C.; Cheng, Z.; Zhu, X. “Iron-mediated (dual) concurrent ATRP/RAFT of water-soluble poly (ethylene glycol) monomethyl ether methacrylate”, Polymer Chemistry 2013, 4, 5664.

 

     联系方式：

               E-mail：sizhangyong@nimte.ac.cn

 

 

 

最后修改：2025-03-25 16:11:45,   访问次数：357